High blood pressure before conception increases the risk of developing pre-eclampsia, a dangerous form of high blood pressure, during pregnancy. As high blood pressure has no symptoms, it can go undetected for years, causing silent damage to blood vessels. High blood pressure can also damage the kidneys, affect eyesight and cause erectile dysfunction. Weight gain increases the risk of developing high blood pressure, which in turn increases the risk of heart attack, stroke and other cardiovascular problems. People taking dolutegravir gained more weight than people taking efavirenz and weight gain was greatest when dolutegravir was combined with tenofovir alafenamide. The ADVANCE study, conducted in South Africa, showed significant differences in weight gain between first-line antiretroviral regimens.
Weight gain is common after starting antiretroviral treatment. Professor Venter said that more research is needed to tease out the relative contributions of antiretroviral drugs and weight gain after starting treatment to the development of high blood pressure in people with HIV. At IAS 2023, Professor Francois Venter talks to NAM aidsmap's Roger Pebody about antiretrovirals and high blood pressure.
0 kommentar(er)
